IGHV3-25

Across TCGA patient cohorts, IGHV3-25 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,970 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-25-associated GO terms across cancer lineages are B cell receptor signaling pathway, Positive regulation of hemopoiesis, and CD4-positive, alpha-beta T cell activation. Each is linked with IGHV3-25 in more than 27 cancer types. Because this analysis shows association rather than direction, both IGHV3-25-to-partner and partner-to-IGHV3-25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGHV3-25-low versus IGHV3-25-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-25→partner) and Y-score (partner→IGHV3-25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	B cell receptor signaling pathway →	+0.081	+0.442	<.001	<.001	3	28
ESCA	Positive regulation of hemopoiesis →	+0.061	+0.598	<.001	<.001	3	27
ESCA	CD4-positive, alpha-beta T cell activation →	+0.057	+0.561	<.001	<.001	3	27
ESCA	B cell proliferation →	+0.060	+0.359	<.001	<.001	3	27
ESCA	B cell mediated immunity →	+0.098	+0.581	<.001	<.001	3	27
ESCA	B cell differentiation →	+0.059	+0.413	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,970 associations by consensus.

B cell receptor signaling pathway by IGHV3-25 expression — ESCA

Explore this box plot interactively →