IGHV3-25

Across TCGA pan-cancer cohorts, IGHV3-25 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of IGHV3-25’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-25 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-25 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV3-25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.855	<.001	9	view →
LUAD	Female	II,III,IV	+1.216	<.001	7	view →
KIRC	All	All	+0.306	<.001	5	view →
BRCA	Female	II,III,IV	−0.330	<.001	4	view →
READ	All	All	−1.282	<.001	3	view →
STAD	All	IV	−2.203	.024	2	view →
UCEC	All	IV	+0.390	.030	2	view →
PAAD	Male	All	+0.330	.022	2	view →
KICH	All	II,III,IV	−0.208	.027	2	view →
HNSC	All	III,IV	+0.402	.028	1	view →
LIHC	Male	All	−0.179	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

IGHV3-25–COAD

Open the COAD breakdown →