IGHV3-25

Across TCGA pan-cancer cohorts, IGHV3-25 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGHV3-25 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-25 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-25 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and SKCM are the cancer types where IGHV3-25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.470	0.241	<.001	132	view →
UCEC	OS	Tertile	III,IV	0.758	0.467	.004	80	view →
SKCM	OS	Median	All	0.407	0.268	<.001	78	view →
UVM	DFS	Tertile	All	0.335	0.779	.004	54	view →
BRCA	OS	Median	All	0.976	0.948	.001	51	view →
STAD	DFS	Quartile	All	0.524	0.718	.003	42	view →
DLBC	OS	Tertile	II,III,IV	0.520	1.000	.003	27	view →
BLCA	DFS	Tertile	All	0.497	0.222	.007	20	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
MESO	OS	Quartile	III,IV	0.720	0.512	.012	16	view →
LGG	DFS	Tertile	All	0.624	0.838	.009	15	view →
OV	OS	Quartile	IV	0.199	0.402	.020	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGHV3-25–HNSC (DFS)

Open the HNSC breakdown →