IGHD4-4

Across TCGA patient cohorts, IGHD4-4 RNA expression is significantly associated with the protein abundance of many other proteins, with 6,832 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD4-4-associated proteins across cancer lineages are TRAF3IP3, WAS, and MZB1. Each is linked with IGHD4-4 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGHD4-4-to-partner and partner-to-IGHD4-4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHD4-4 versus TRAF3IP3 in LSCC, with a Pearson correlation of 0.57.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD4-4→partner) and Y-score (partner→IGHD4-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRAF3IP3 →	+0.588	+2.106	<.001	<.001	3	6
UCEC	WAS →	+0.504	+0.907	<.001	.002	3	6
UCEC	MZB1 →	+1.250	+1.647	<.001	.001	3	6
LSCC	ARHGAP45 →	+0.488	+1.894	<.001	<.001	3	6
BRCA	PRKCB →	+0.569	+0.822	.001	.001	3	6
LSCC	RASAL3 →	+0.442	+1.904	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,832 associations by consensus.

IGHD4-4 vs TRAF3IP3 — LSCC

Explore this scatter interactively →