IGHD4-4

Across TCGA pan-cancer cohorts, IGHD4-4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGHD4-4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHD4-4 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHD4-4 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHD4-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD4-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.961	.003	5	view →
LUAD	All	All	+0.577	.005	4	view →
KIRC	All	All	+0.211	.007	4	view →
ESCA	All	All	+1.073	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGHD4-4–COAD

Open the COAD breakdown →