Q-omics provides the consensus-scored IGHD4-4 profile across patient tissues and cancer cell-line models. IGHD4-4 expression is associated with patient survival in 8 of 34 cancer types, with the highest sampling consensus in DLBC. Among the 18 cancer types available for tumor–normal comparison, IGHD4-4 is differentially expressed in 4, with the highest sampling consensus in COAD. Additionally, IGHD4-4 RNA expression shows 8,169 significant gene co-expression associations, with the highest sampling consensus in LAML. Together, these results highlight DLBC, COAD, and LAML as cancer lineages where IGHD4-4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for IGHD4-4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes IGHD4-4 survival associations across molecular data types. IGHD4-4 RNA expression shows survival associations in the most cancer types (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible IGHD4-4 RNA expression–survival associations across cancer types. High IGHD4-4 expression shows unfavorable associations in DLBC and STAD, but favorable associations in HNSC, SKCM, ESCA and LUAD. The DLBC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify DLBC as the clearest survival context for IGHD4-4 RNA expression.
This table summarizes IGHD4-4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for IGHD4-4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. IGHD4-4 shows lower tumor expression in COAD and higher tumor expression in LUAD, KIRC and ESCA. The COAD box plot shows higher IGHD4-4 RNA expression in normal versus tumor tissue (log2 FC = −0.961, t-test p = .003).
This table shows molecular features associated with IGHD4-4 in patient tissues and cancer cell lines. In patient samples, IGHD4-4 shows the broadest associations at the RNA and protein expression levels, with LAML recurring as the lineage with the largest associated feature set.
