IGHD4-4

Across TCGA pan-cancer cohorts, IGHD4-4 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated IGHD4-4 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher IGHD4-4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHD4-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

DLBC, HNSC, and SKCM are the cancer types where IGHD4-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	All	0.056	0.888	<.001	78	view →
HNSC	DFS	Tertile	All	0.775	0.586	.007	51	view →
SKCM	DFS	Tertile	All	0.368	0.185	.003	45	view →
ESCA	DFS	Tertile	II,III,IV	0.620	0.319	.021	42	view →
STAD	DFS	Quartile	II,III,IV	0.392	0.564	.022	29	view →
LUAD	DFS	Tertile	All	0.752	0.637	.015	27	view →
READ	DFS	Tertile	IV	0.255	0.628	.020	9	view →
BRCA	DFS	Tertile	All	0.833	0.503	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

IGHD4-4–DLBC (OS)

Open the DLBC breakdown →