IER2

Across TCGA patient cohorts, IER2 protein abundance is significantly associated with the RNA expression of many other genes, with 394 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IER2-associated genes across cancer lineages are NDFIP1, DUSP6, and NLGN4X. Each is linked with IER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IER2-to-partner and partner-to-IER2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IER2 versus NDFIP1 in HNSC, with a Pearson correlation of 0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IER2→partner) and Y-score (partner→IER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NDFIP1 →	+0.672	+0.594	<.001	.003	3	1
HNSC	DUSP6 →	+1.519	+0.770	.007	.009	3	1
HNSC	NLGN4X →	+3.525	+0.717	<.001	.005	3	1
HNSC	PALM2AKAP2 →	+0.769	+0.552	.002	.007	3	1
HNSC	FAM86KP →	-0.502	-0.717	.005	.005	3	1
HNSC	RNU6-733P →	+1.650	+0.612	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 394 associations by consensus.

IER2 vs NDFIP1 — HNSC

Explore this scatter interactively →