family with sequence similarity 86 member K, pseudogeneGenealiases: []
Q-omics provides the consensus-scored FAM86KP profile across patient tissues and cancer cell-line models. FAM86KP expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in READ. Among the 18 cancer types available for tumor–normal comparison, FAM86KP is differentially expressed in 6, with the highest sampling consensus in THCA. Additionally, FAM86KP RNA expression shows 14,038 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight READ, THCA, and THYM as cancer lineages where FAM86KP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM86KP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM86KP survival associations across molecular data types. FAM86KP RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM86KP RNA expression–survival associations across cancer types. High FAM86KP expression shows unfavorable associations in LAML, KIRP and THCA, but favorable associations in READ, HNSC and LUAD. The READ Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .002). Together, the overview and detailed table identify READ as the clearest survival context for FAM86KP RNA expression.
This table summarizes FAM86KP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for FAM86KP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM86KP shows lower tumor expression in THCA, KICH and LUAD and higher tumor expression in COAD, CHOL and LUSC. The THCA box plot shows higher FAM86KP RNA expression in normal versus tumor tissue (log2 FC = −0.240, t-test p < 0.001).
This table shows molecular features associated with FAM86KP in patient tissues and cancer cell lines. In patient samples, FAM86KP shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM86KP RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER.
