IER2

Across TCGA pan-cancer cohorts, IER2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IER2 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher IER2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IER2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

ACC, LGG, and UVM are the cancer types where IER2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.216	0.687	<.001	94	view →
LGG	OS	Tertile	All	0.766	0.902	<.001	41	view →
UVM	DFS	Tertile	III,IV	0.333	0.812	.001	28	view →
SKCM	OS	Tertile	IV	0.724	0.240	.005	28	view →
ESCA	OS	Median	II,III,IV	0.419	0.667	.001	27	view →
SCLC	DFS	Tertile	All	0.554	0.297	.007	26	view →
LUAD	DFS	Quartile	IV	0.378	0.829	.011	25	view →
KIRC	DFS	Tertile	All	0.863	0.696	.004	20	view →
KIRP	DFS	Quartile	III,IV	0.449	0.747	.028	12	view →
KICH	DFS	Median	II,III,IV	1.000	0.481	.010	8	view →
UCEC	DFS	Quartile	All	0.480	0.785	.014	6	view →
CHOL	DFS	Quartile	All	1.000	0.162	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IER2–ACC (DFS)

Open the ACC breakdown →