HTR3B

Across TCGA cell cohorts, HTR3B mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTR3B-associated genes across cancer lineages are OR1N2, IL26, and FCRL2. Each is linked with HTR3B in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR3B-to-partner and partner-to-HTR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1N2 grouped by HTR3B-low versus HTR3B-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3B→partner) and Y-score (partner→HTR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1N2 →	+0.025	+5.029	<.001	.006	3	1
LARGE_INTESTINE	IL26 →	+0.568	+3.793	<.001	.007	3	1
LARGE_INTESTINE	FCRL2 →	+0.043	+4.000	.006	.004	3	1
LARGE_INTESTINE	UNC5D →	+0.065	+4.032	<.001	.004	3	1
LARGE_INTESTINE	SHOX →	+0.046	+3.793	<.001	.007	3	1
CNS	OR52N5 →	+0.009	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR1N2 by HTR3B expression — LUNG_SCLC

Explore this box plot interactively →