HTR3B

Across TCGA pan-cancer cohorts, HTR3B RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated HTR3B data layer compared with 5 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher HTR3B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HTR3B expression acts as an unfavorable survival marker, although some lineages such as UVM and CESC show a favorable association.

MESO, THYM, and UVM are the cancer types where HTR3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	IV	0.036	0.602	<.001	72	view →
THYM	OS	Tertile	All	0.494	0.943	<.001	54	view →
UVM	DFS	Tertile	All	0.779	0.446	.004	37	view →
CESC	OS	Median	II,III,IV	0.928	0.762	.009	30	view →
ESCA	OS	Tertile	III,IV	0.760	0.406	.001	24	view →
UCEC	DFS	Median	IV	0.810	0.518	.009	20	view →
LAML	DFS	Quartile	All	0.768	0.483	<.001	20	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
COAD	DFS	Tertile	IV	0.319	0.516	.031	18	view →
LIHC	OS	Tertile	All	0.540	0.738	.004	12	view →
HNSC	OS	Median	IV	0.484	0.341	.027	7	view →
DLBC	OS	Quartile	II,III,IV	0.148	0.956	.009	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

HTR3B–MESO (OS)

Open the MESO breakdown →