HSPE1

Across TCGA patient cohorts, HSPE1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. KIRP shows the largest number of these associations.

The most reproducible HSPE1-associated genes across cancer lineages are MIR6737, TSPY25P, and OR4B1. Each is linked with HSPE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPE1-to-partner and partner-to-HSPE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6737 grouped by HSPE1-low versus HSPE1-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPE1→partner) and Y-score (partner→HSPE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	MIR6737 →	+0.513	+5.376	<.001	.005	3	1
UCEC	TSPY25P →	+0.094	+8.066	<.001	.007	3	1
KIRP	OR4B1 →	+0.089	+5.060	<.001	.008	3	1
KIRP	RN7SKP134 →	+0.159	+5.060	<.001	.008	3	1
KIRP	MIR875 →	+0.493	+5.770	<.001	.003	3	1
KIRP	RPL37P4 →	+0.167	+5.264	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MIR6737 by HSPE1 expression — KIRP

Explore this box plot interactively →