HSPE1

Across TCGA pan-cancer cohorts, HSPE1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated HSPE1 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HSPE1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSPE1 expression acts as an unfavorable survival marker, although some lineages such as READ and BLCA show a favorable association.

ACC, UVM, and LIHC are the cancer types where HSPE1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.208	0.690	<.001	94	view →
UVM	DFS	Quartile	All	0.347	0.838	<.001	85	view →
LIHC	OS	Quartile	All	0.598	0.806	<.001	74	view →
ESCA	OS	Quartile	II,III,IV	0.300	0.634	<.001	67	view →
KIRP	DFS	Tertile	All	0.531	0.723	<.001	63	view →
LUAD	DFS	Median	All	0.747	0.881	<.001	58	view →
LGG	OS	Median	All	0.734	0.878	<.001	38	view →
UCS	DFS	Tertile	IV	0.237	0.975	.024	36	view →
READ	OS	Median	III,IV	0.724	0.272	.002	27	view →
THYM	DFS	Median	III,IV	0.471	1.000	.008	25	view →
SCLC	DFS	Median	II,III,IV	0.190	0.833	<.001	25	view →
CHOL	DFS	Tertile	II,III,IV	0.170	0.591	.010	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

HSPE1–ACC (DFS)

Open the ACC breakdown →