HSPE1

Across TCGA pan-cancer cohorts, HSPE1 RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of HSPE1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HSPE1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSPE1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, BLCA, and STAD are the cancer types where HSPE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.212	<.001	11	view →
BLCA	Female	III,IV	+1.125	<.001	11	view →
STAD	Female	All	+1.495	<.001	9	view →
LUAD	Male	II,III,IV	+1.147	<.001	9	view →
LIHC	Male	III,IV	+1.035	<.001	9	view →
LUSC	Female	All	+1.684	<.001	8	view →
HNSC	Male	IV	+1.368	<.001	8	view →
UCEC	All	III,IV	+1.314	<.001	8	view →
KIRP	All	II,III,IV	+0.620	<.001	8	view →
BRCA	All	III,IV	+0.955	<.001	6	view →
KICH	Female	All	−0.723	<.001	4	view →
KIRC	All	II,III,IV	+0.227	.014	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

HSPE1–COAD

Open the COAD breakdown →