HSPA6

Across TCGA patient cohorts, HSPA6 protein abundance is significantly associated with the RNA expression of many other genes, with 7,133 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HSPA6-associated genes across cancer lineages are PPP6C, GTF3C4, and CST7. Each is linked with HSPA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSPA6-to-partner and partner-to-HSPA6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSPA6 versus PPP6C in CCRCC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA6→partner) and Y-score (partner→HSPA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PPP6C →	+0.410	+0.310	<.001	<.001	3	3
LSCC	GTF3C4 →	+0.401	+0.297	<.001	.001	3	3
LSCC	CST7 →	-0.784	-0.370	<.001	<.001	3	3
LSCC	LENEP →	+0.774	+0.355	<.001	<.001	3	2
GBM	ERO1A →	+0.833	+0.420	<.001	.001	3	2
LUAD	RNU4-38P →	+1.196	+0.287	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,133 associations by consensus.

HSPA6 vs PPP6C — CCRCC

Explore this scatter interactively →