HSPA6

Across TCGA pan-cancer cohorts, HSPA6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HSPA6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HSPA6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSPA6 is over-expressed in tumor, although a few such as HNSC and PRAD show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where HSPA6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPA6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.612	<.001	11	view →
COAD	Female	II,III,IV	+1.248	<.001	10	view →
KIRP	Male	All	+1.642	<.001	8	view →
READ	All	All	+1.636	.014	6	view →
BRCA	All	All	+0.984	<.001	6	view →
STAD	Male	All	+0.709	.002	6	view →
THCA	All	III,IV	+1.102	.007	4	view →
UCEC	All	All	+1.070	.042	4	view →
CHOL	All	All	+1.437	<.001	3	view →
HNSC	Female	All	−0.869	.036	2	view →
PRAD	All	All	−0.810	.043	2	view →
LIHC	All	II,III,IV	+0.767	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HSPA6–KIRC

Open the KIRC breakdown →