Across TCGA patient cohorts, HSD17B11 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B11-associated genes across cancer lineages are Notch1, VHL, and ATM. Each is linked with HSD17B11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B11-to-partner and partner-to-HSD17B11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B11→partner) and Y-score (partner→HSD17B11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.160	+2.009	.005	.017	3	1
UCEC	VHL →	-0.975	-1.807	<.001	.027	3	1
UCEC	ATM →	-0.428	-1.807	.022	.027	3	1
UCEC	Caspase-8 →	-0.242	-3.780	.019	<.001	3	1
UCEC	Cyclin-B1 →	+0.490	+2.321	.034	.006	3	1
UCEC	BRCA2 →	-0.136	-2.311	.011	.034	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

HSD17B11 survival (RNA) · tumor vs normal (RNA) · all HSD17B11 data types