Across TCGA pan-cancer cohorts, HSD17B11 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HSD17B11’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where HSD17B11 RNA is repressed in tumor relative to normal tissue. In most cancer types HSD17B11 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.
COAD, KIRC, and KICH are the cancer types where HSD17B11 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSD17B11 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.