HRH3

Across TCGA patient cohorts, HRH3 mutation is significantly associated with the RNA expression of many other genes, with 1,617 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HRH3-associated genes across cancer lineages are MRPS18BP2, YBX1P9, and RNU6-42P. Each is linked with HRH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HRH3-to-partner and partner-to-HRH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS18BP2 grouped by HRH3-low versus HRH3-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH3→partner) and Y-score (partner→HRH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MRPS18BP2 →	+0.065	+5.108	<.001	.008	3	2
LIHC	YBX1P9 →	+0.119	+5.758	<.001	.003	3	2
LUSC	RNU6-42P →	+0.491	+3.702	.001	.007	3	2
LUSC	MIR6780A →	+0.446	+3.482	<.001	.003	3	2
COAD	COX6B1P7 →	+0.629	+6.392	<.001	.001	3	2
COAD	RPL12P5 →	+0.420	+5.357	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,617 associations by consensus.

MRPS18BP2 by HRH3 expression — LIHC

Explore this box plot interactively →