HOXD11

Across TCGA patient cohorts, HOXD11 mutation is significantly associated with the RNA expression of many other genes, with 282 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD11-associated genes across cancer lineages are E2F6P1, RN7SL354P, and RNA5SP436. Each is linked with HOXD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD11-to-partner and partner-to-HOXD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E2F6P1 grouped by HOXD11-low versus HOXD11-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD11→partner) and Y-score (partner→HOXD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	E2F6P1 →	+0.084	+5.099	<.001	.008	3	2
UCEC	RN7SL354P →	+0.268	+2.374	<.001	.006	3	2
UCEC	RNA5SP436 →	+0.224	+3.352	.007	.004	3	2
UCEC	SNORD91B →	+0.413	+3.599	.007	.002	3	1
UCEC	RN7SL197P →	+0.167	+2.599	.001	.009	3	1
UCEC	WHAMMP3 →	+0.200	+3.566	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 282 associations by consensus.

E2F6P1 by HOXD11 expression — LUAD

Explore this box plot interactively →