HOXD11

Across TCGA pan-cancer cohorts, HOXD11 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HOXD11’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXD11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXD11 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where HOXD11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXD11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+2.791	<.001	12	view →
KICH	Male	All	−2.726	<.001	11	view →
KIRC	Male	II,III,IV	−0.976	<.001	10	view →
LUSC	Female	All	+2.302	<.001	6	view →
CHOL	All	II,III,IV	+0.095	.002	4	view →
COAD	Male	II,III,IV	−0.802	.010	3	view →
READ	Female	All	−2.064	.004	2	view →
UCEC	All	All	−1.168	.015	2	view →
KIRP	All	All	−1.131	<.001	2	view →
PRAD	All	All	−0.979	<.001	2	view →
PAAD	Female	All	+0.110	.016	2	view →
BRCA	All	III,IV	+0.087	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HOXD11–HNSC

Open the HNSC breakdown →