HOXD11

Across TCGA pan-cancer cohorts, HOXD11 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HOXD11 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HOXD11 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXD11 expression acts as an unfavorable survival marker, although some lineages such as SKCM and ESCA show a favorable association.

KIRP, STAD, and BLCA are the cancer types where HOXD11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.517	0.905	<.001	143	view →
STAD	OS	Tertile	II,III,IV	0.565	0.742	<.001	72	view →
BLCA	DFS	Quartile	All	0.543	0.712	.001	62	view →
ACC	DFS	Tertile	All	0.183	0.777	<.001	55	view →
LGG	DFS	Median	All	0.600	0.834	<.001	54	view →
LUAD	DFS	Median	All	0.748	0.855	<.001	49	view →
SKCM	DFS	Median	IV	0.638	0.239	.026	26	view →
GBM	DFS	Tertile	All	0.181	0.332	.002	24	view →
LIHC	OS	Tertile	III,IV	0.302	0.582	.018	18	view →
ESCA	DFS	Median	All	0.930	0.450	.003	15	view →
OV	DFS	Tertile	II,III,IV	0.484	0.583	.022	14	view →
TGCT	DFS	Quartile	All	0.707	0.932	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HOXD11–KIRP (OS)

Open the KIRP breakdown →