HOXC5

Across TCGA patient cohorts, HOXC5 mutation is significantly associated with the RNA expression of many other genes, with 874 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXC5-associated genes across cancer lineages are RN7SL815P, H3P18, and DPRXP7. Each is linked with HOXC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC5-to-partner and partner-to-HOXC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL815P grouped by HOXC5-low versus HOXC5-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC5→partner) and Y-score (partner→HOXC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL815P →	+0.192	+5.812	<.001	.003	3	2
CESC	H3P18 →	+1.796	+5.539	<.001	.004	3	2
CESC	DPRXP7 →	+0.145	+7.164	<.001	<.001	3	2
UCEC	MIR4527HG →	+0.120	+2.679	.009	.001	3	2
UCEC	RNA5SP463 →	+0.466	+2.258	<.001	.004	3	2
CESC	HTR1A →	+0.123	+5.201	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 874 associations by consensus.

RN7SL815P by HOXC5 expression — CESC

Explore this box plot interactively →