HOXC5

Across TCGA pan-cancer cohorts, HOXC5 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated HOXC5 data layer compared with 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HOXC5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXC5 expression acts as an unfavorable survival marker, although some lineages such as MESO and BRCA show a favorable association.

COAD, HNSC, and LGG are the cancer types where HOXC5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.724	0.844	<.001	74	view →
HNSC	OS	Quartile	All	0.697	0.841	.001	58	view →
LGG	DFS	Median	All	0.284	0.496	<.001	49	view →
LUAD	DFS	Tertile	All	0.598	0.734	.002	43	view →
MESO	OS	Tertile	All	0.559	0.326	.007	39	view →
BRCA	OS	Tertile	III,IV	0.957	0.820	.002	35	view →
UVM	OS	Tertile	All	0.581	0.808	.029	33	view →
CESC	DFS	Tertile	All	0.777	0.905	.001	30	view →
UCEC	OS	Quartile	All	0.823	0.896	.019	20	view →
LIHC	DFS	Quartile	II,III,IV	0.267	0.498	.013	18	view →
LAML	DFS	Tertile	All	0.705	0.517	.021	18	view →
PRAD	DFS	Quartile	All	0.692	0.879	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

HOXC5–COAD (OS)

Open the COAD breakdown →