Q-omics provides the consensus-scored HOXC-AS3 profile across patient tissues and cancer cell-line models. HOXC-AS3 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, HOXC-AS3 is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, HOXC-AS3 RNA expression shows 9,997 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight ACC, KIRC, and KIRP as cancer lineages where HOXC-AS3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HOXC-AS3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HOXC-AS3 survival associations across molecular data types. HOXC-AS3 RNA expression shows survival associations in the most cancer types (26). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HOXC-AS3 RNA expression–survival associations across cancer types. High HOXC-AS3 expression shows unfavorable associations in ACC, COAD, THYM, LGG and CESC, but favorable associations in KIRP. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for HOXC-AS3 RNA expression.
This table summarizes HOXC-AS3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for HOXC-AS3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HOXC-AS3 shows lower tumor expression in KIRC and KICH and higher tumor expression in HNSC, BRCA, UCEC and STAD. The KIRC box plot shows higher HOXC-AS3 RNA expression in normal versus tumor tissue (log2 FC = −1.726, t-test p < 0.001).
This table shows molecular features associated with HOXC-AS3 in patient tissues and cancer cell lines. In patient samples, HOXC-AS3 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set.
