HOXC-AS3

Across TCGA pan-cancer cohorts, HOXC-AS3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HOXC-AS3 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HOXC-AS3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOXC-AS3 expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCS show a favorable association.

ACC, COAD, and THYM are the cancer types where HOXC-AS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.395	0.809	<.001	162	view →
COAD	OS	Tertile	All	0.797	0.893	<.001	88	view →
THYM	OS	Tertile	III,IV	0.229	1.000	<.001	69	view →
LGG	DFS	Tertile	All	0.573	0.808	<.001	54	view →
KIRP	OS	Quartile	All	0.975	0.866	.003	48	view →
UVM	OS	Tertile	III,IV	0.229	0.836	.001	30	view →
CESC	DFS	Tertile	All	0.750	0.873	.004	30	view →
READ	DFS	Tertile	All	0.352	0.715	.002	26	view →
UCS	DFS	Tertile	II,III,IV	0.561	0.170	.020	24	view →
OV	DFS	Median	III,IV	0.332	0.406	.019	22	view →
STAD	DFS	Quartile	III,IV	0.741	0.403	.027	18	view →
LIHC	DFS	Tertile	All	0.356	0.581	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HOXC-AS3–ACC (OS)

Open the ACC breakdown →