HOXC-AS3

Across TCGA pan-cancer cohorts, HOXC-AS3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HOXC-AS3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOXC-AS3 RNA is repressed in tumor relative to normal tissue. In most cancer types HOXC-AS3 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where HOXC-AS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXC-AS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.726	<.001	12	view →
KICH	Male	All	−2.689	<.001	11	view →
HNSC	Male	All	+0.160	<.001	10	view →
BRCA	All	II,III,IV	+0.696	<.001	8	view →
UCEC	All	IV	+1.335	<.001	6	view →
STAD	Male	II,III,IV	+0.694	<.001	6	view →
LUSC	All	All	+0.535	<.001	6	view →
LUAD	All	All	+0.262	<.001	4	view →
ESCA	All	II,III,IV	+0.645	.012	2	view →
BLCA	All	All	+0.355	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HOXC-AS3–KIRC

Open the KIRC breakdown →