HOXA10

Across TCGA patient cohorts, HOXA10 mutation is significantly associated with the RNA expression of many other genes, with 481 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXA10-associated genes across cancer lineages are UBE2V1P4, RN7SL248P, and SRSF3P6. Each is linked with HOXA10 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXA10-to-partner and partner-to-HOXA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2V1P4 grouped by HOXA10-low versus HOXA10-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXA10→partner) and Y-score (partner→HOXA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	UBE2V1P4 →	+0.091	+3.366	<.001	.006	3	2
CESC	RN7SL248P →	+0.079	+5.000	<.001	.001	3	2
BLCA	SRSF3P6 →	+0.120	+3.241	.006	.009	3	2
BLCA	RNU6-250P →	+0.295	+3.432	.001	.009	3	2
UCEC	RNU6-718P →	+0.222	+4.292	<.001	<.001	3	2
UCEC	METTL16 →	+0.769	+3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 481 associations by consensus.

UBE2V1P4 by HOXA10 expression — CESC

Explore this box plot interactively →