HOXA10

Across TCGA pan-cancer cohorts, HOXA10 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HOXA10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOXA10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HOXA10 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

HNSC, LUAD, and STAD are the cancer types where HOXA10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOXA10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.878	<.001	12	view →
LUAD	All	III,IV	+1.493	<.001	10	view →
STAD	Male	II,III,IV	+2.737	<.001	9	view →
LUSC	Female	All	+2.775	<.001	8	view →
KIRP	Male	II,III,IV	+1.030	<.001	8	view →
BRCA	All	All	−1.130	<.001	6	view →
LIHC	Female	All	+1.022	<.001	5	view →
PAAD	All	All	+2.502	.002	4	view →
UCEC	All	II,III,IV	+2.021	.020	2	view →
CHOL	All	All	+1.714	.006	2	view →
BLCA	Male	IV	−1.350	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HOXA10–HNSC

Open the HNSC breakdown →