HOPX

Across TCGA patient cohorts, HOPX mutation is significantly associated with the RNA expression of many other genes, with 269 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOPX-associated genes across cancer lineages are ELOAP1, MIR615, and RNU7-29P. Each is linked with HOPX in more than 1 cancer types. Because this analysis shows association rather than direction, both HOPX-to-partner and partner-to-HOPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOAP1 grouped by HOPX-low versus HOPX-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOPX→partner) and Y-score (partner→HOPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ELOAP1 →	+0.040	+5.917	<.001	.001	3	2
UCEC	MIR615 →	+0.311	+2.869	<.001	.001	3	2
UCEC	RNU7-29P →	+0.276	+3.847	<.001	.001	3	2
UCEC	SNRPCP20 →	+0.216	+2.633	.001	.001	3	2
UCEC	C2orf50 →	-0.925	-3.443	.005	.005	3	1
UCEC	FAM177A1 →	+0.449	+2.595	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 269 associations by consensus.

ELOAP1 by HOPX expression — COAD

Explore this box plot interactively →