HOPX

Across TCGA pan-cancer cohorts, HOPX RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HOPX’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HOPX RNA is repressed in tumor relative to normal tissue. In most cancer types HOPX is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, KICH, and LUAD are the cancer types where HOPX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOPX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−2.720	<.001	11	view →
KICH	Female	All	−1.665	<.001	10	view →
LUAD	Male	All	−1.605	<.001	9	view →
LUSC	Female	II,III,IV	−3.642	<.001	7	view →
BRCA	All	III,IV	+1.046	<.001	6	view →
LIHC	All	All	+0.464	<.001	6	view →
CHOL	All	All	+1.894	<.001	3	view →
UCEC	All	All	−1.328	<.001	2	view →
PRAD	All	All	−0.661	<.001	2	view →
STAD	Female	III,IV	+0.609	.035	1	view →
KIRP	All	All	−0.488	.044	1	view →
COAD	All	All	+0.478	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HOPX–HNSC

Open the HNSC breakdown →