HOPX

Across TCGA pan-cancer cohorts, HOPX RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HOPX data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HOPX RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOPX expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

KIRP, UVM, and LGG are the cancer types where HOPX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.530	0.833	<.001	119	view →
UVM	DFS	Tertile	All	0.333	0.754	<.001	82	view →
LGG	DFS	Median	All	0.657	0.811	<.001	50	view →
LAML	DFS	Tertile	All	0.216	0.544	<.001	36	view →
SKCM	DFS	Median	All	0.252	0.170	.004	32	view →
HNSC	DFS	Quartile	II,III,IV	0.761	0.594	.004	28	view →
ACC	OS	Quartile	All	0.923	0.409	.014	23	view →
LUSC	DFS	Median	All	0.322	0.445	.010	22	view →
CESC	DFS	Median	All	0.873	0.768	.003	18	view →
STAD	OS	Median	All	0.637	0.814	.011	18	view →
LUAD	DFS	Quartile	All	0.853	0.733	.002	15	view →
SCLC	OS	Tertile	III,IV	0.471	0.841	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HOPX–KIRP (DFS)

Open the KIRP breakdown →