HMGCS1

Across TCGA patient cohorts, HMGCS1 mutation is significantly associated with the RNA expression of many other genes, with 1,724 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGCS1-associated genes across cancer lineages are CKS1BP6, MIR518A1, and PPIAP27. Each is linked with HMGCS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGCS1-to-partner and partner-to-HMGCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CKS1BP6 grouped by HMGCS1-low versus HMGCS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCS1→partner) and Y-score (partner→HMGCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CKS1BP6 →	+0.360	+1.813	<.001	.003	3	2
HNSC	MIR518A1 →	+0.413	+5.822	<.001	.003	3	2
BRCA	PPIAP27 →	+0.092	+4.760	.001	.007	3	2
LUAD	OR9A3P →	+0.154	+3.842	.002	.005	3	2
SKCM	VN1R71P →	+0.216	+3.211	.001	.005	3	2
SKCM	MIR5692C1 →	+0.415	+4.913	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,724 associations by consensus.

CKS1BP6 by HMGCS1 expression — UCEC

Explore this box plot interactively →