HMGCS1

Across TCGA pan-cancer cohorts, HMGCS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HMGCS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HMGCS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGCS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where HMGCS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGCS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.264	<.001	10	view →
KIRC	Male	III,IV	−0.538	<.001	8	view →
LIHC	All	III,IV	+1.552	<.001	7	view →
BLCA	Male	III,IV	+1.441	.001	7	view →
LUAD	Male	All	−1.033	<.001	7	view →
BRCA	All	III,IV	+0.677	<.001	6	view →
CHOL	All	All	−1.392	.005	2	view →
LUSC	All	All	+0.510	.002	2	view →
KICH	All	All	−0.464	.037	1	view →
KIRP	Male	All	−0.461	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HMGCS1–THCA

Open the THCA breakdown →