high mobility group box 1 pseudogene 5Genealiases: HMG-1 · HMG1L5 · HMGB1L15 · HMGB1L5 · HMGB1P2
Q-omics provides the consensus-scored HMGB1P5 profile across patient tissues and cancer cell-line models. HMGB1P5 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, HMGB1P5 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, HMGB1P5 RNA expression shows 19,391 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight UVM, HNSC, and ACC as cancer lineages where HMGB1P5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HMGB1P5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HMGB1P5 survival associations across molecular data types. HMGB1P5 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HMGB1P5 RNA expression–survival associations across cancer types. High HMGB1P5 expression shows unfavorable associations in UVM, ACC, ESCA and KIRP, but favorable associations in KIRC and THCA. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for HMGB1P5 RNA expression.
This table summarizes HMGB1P5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 1. The strongest signals are observed in HNSC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for HMGB1P5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HMGB1P5 shows lower tumor expression in KICH and higher tumor expression in HNSC, BLCA, STAD, CHOL and LIHC. The HNSC box plot shows higher HMGB1P5 RNA expression in tumor versus normal tissue (log2 FC = +0.665, t-test p < 0.001).
This table shows molecular features associated with HMGB1P5 in patient tissues and cancer cell lines. In patient samples, HMGB1P5 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
