HMGB1P5

Across TCGA patient cohorts, HMGB1P5 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGB1P5-associated genes across cancer lineages are ARL2BPP2, MRPS31P1, and MIR6803. Each is linked with HMGB1P5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB1P5-to-partner and partner-to-HMGB1P5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARL2BPP2 grouped by HMGB1P5-low versus HMGB1P5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P5→partner) and Y-score (partner→HMGB1P5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARL2BPP2 →	+0.042	+4.242	<.001	.006	3	2
UCEC	MRPS31P1 →	+0.232	+3.186	<.001	.008	3	1
UCEC	MIR6803 →	+0.245	+5.671	<.001	<.001	3	1
UCEC	OR5J1P →	+0.082	+3.097	.009	.004	3	1
UCEC	MYCLP1 →	+0.141	+2.715	.003	.006	3	1
UCEC	MIR589 →	+1.160	+3.627	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ARL2BPP2 by HMGB1P5 expression — UCEC

Explore this box plot interactively →