HMGB1P5

Across TCGA patient cohorts, HMGB1P5 protein abundance is significantly associated with the RNA expression of many other genes, with 1,465 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGB1P5-associated genes across cancer lineages are SLC25A15, XPO4, and ENPP7P2. Each is linked with HMGB1P5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB1P5-to-partner and partner-to-HMGB1P5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGB1P5 versus SLC25A15 in LSCC, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P5→partner) and Y-score (partner→HMGB1P5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC25A15 →	+0.739	+0.750	.001	.002	3	2
LSCC	XPO4 →	+0.547	+0.758	.001	.001	3	2
LSCC	ENPP7P2 →	+0.700	+0.925	.003	.003	3	2
LSCC	WDR36 →	+0.410	+0.718	.006	.007	3	2
UCEC	KDELR3 →	+0.611	+0.384	.004	.008	3	1
UCEC	EEF2K →	+0.552	+0.739	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,465 associations by consensus.

HMGB1P5 vs SLC25A15 — LSCC

Explore this scatter interactively →