high mobility group AT-hook 1 pseudogene 2Genealiases: HMGA1L2 · HMGIYL2
Q-omics provides the consensus-scored HMGA1P2 profile across patient tissues and cancer cell-line models. HMGA1P2 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, HMGA1P2 is differentially expressed in 14, with the highest sampling consensus in COAD. Additionally, HMGA1P2 RNA expression shows 18,268 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, COAD, and THYM as cancer lineages where HMGA1P2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HMGA1P2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HMGA1P2 survival associations across molecular data types. HMGA1P2 RNA expression shows survival associations in the most cancer types (25). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HMGA1P2 RNA expression–survival associations across cancer types. High HMGA1P2 expression shows unfavorable associations in UVM, LGG and CHOL, but favorable associations in HNSC, UCS and SKCM. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .003). Together, the overview and detailed table identify HNSC as the clearest survival context for HMGA1P2 RNA expression.
This table summarizes HMGA1P2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for HMGA1P2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HMGA1P2 shows higher tumor expression in COAD, STAD, BLCA, KICH, HNSC and LUSC. The COAD box plot shows higher HMGA1P2 RNA expression in tumor versus normal tissue (log2 FC = +1.761, t-test p < 0.001).
This table shows molecular features associated with HMGA1P2 in patient tissues and cancer cell lines. In patient samples, HMGA1P2 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
