HMGA1P2

Across TCGA pan-cancer cohorts, HMGA1P2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HMGA1P2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HMGA1P2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HMGA1P2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, UVM, and LGG are the cancer types where HMGA1P2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.524	0.279	.003	63	view →
UVM	DFS	Tertile	III,IV	0.381	0.866	.001	49	view →
LGG	DFS	Median	All	0.322	0.465	<.001	38	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
CHOL	DFS	Median	II,III,IV	0.145	0.564	.003	20	view →
SKCM	OS	Quartile	III,IV	0.810	0.499	.001	20	view →
LIHC	DFS	Tertile	All	0.429	0.605	<.001	20	view →
ACC	OS	Quartile	All	1.000	0.370	.006	20	view →
BLCA	DFS	Quartile	IV	0.506	0.241	.006	19	view →
LUAD	DFS	Median	All	0.269	0.414	.020	19	view →
KIRC	DFS	Median	All	0.574	0.675	.009	16	view →
THCA	DFS	Median	IV	0.464	0.801	.012	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

HMGA1P2–HNSC (OS)

Open the HNSC breakdown →