HMGA1P2

Across TCGA pan-cancer cohorts, HMGA1P2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HMGA1P2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HMGA1P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGA1P2 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

COAD, STAD, and BLCA are the cancer types where HMGA1P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGA1P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.761	<.001	11	view →
STAD	All	II,III,IV	+1.049	<.001	9	view →
BLCA	All	All	+0.788	<.001	9	view →
KICH	All	II,III,IV	+0.696	<.001	8	view →
HNSC	All	All	+0.323	<.001	6	view →
LUSC	Male	II,III,IV	+0.601	<.001	5	view →
LIHC	Female	II,III,IV	+0.561	<.001	5	view →
LUAD	All	All	+0.571	<.001	3	view →
READ	Female	All	+1.046	<.001	2	view →
KIRP	All	IV	+0.965	<.001	2	view →
CHOL	All	All	+0.951	<.001	2	view →
UCEC	All	All	+0.536	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HMGA1P2–COAD

Open the COAD breakdown →