HLTF

Across TCGA patient cohorts, HLTF protein abundance is significantly associated with the RNA expression of many other genes, with 20,204 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLTF-associated genes across cancer lineages are WDR53, RAD51AP1, and KIF20A. Each is linked with HLTF in more than 6 cancer types. Because this analysis shows association rather than direction, both HLTF-to-partner and partner-to-HLTF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLTF versus WDR53 in LSCC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLTF→partner) and Y-score (partner→HLTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR53 →	+0.691	+0.500	<.001	<.001	3	7
LUAD	RAD51AP1 →	+0.960	+0.326	<.001	<.001	3	6
HNSC	KIF20A →	+1.135	+0.328	<.001	.001	3	6
LSCC	GMPS →	+0.879	+0.603	<.001	<.001	3	6
LSCC	POLR2H →	+0.641	+0.491	<.001	<.001	3	6
HNSC	RFC4 →	+1.040	+0.374	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,204 associations by consensus.

HLTF vs WDR53 — LSCC

Explore this scatter interactively →