HLTF

Across TCGA pan-cancer cohorts, HLTF RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HLTF’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HLTF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLTF is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where HLTF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLTF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.551	<.001	11	view →
LIHC	Female	II,III,IV	+1.269	<.001	9	view →
THCA	Male	All	−0.841	<.001	9	view →
LUAD	Male	III,IV	+1.603	<.001	8	view →
BRCA	All	III,IV	+0.816	<.001	6	view →
KIRC	Male	II,III,IV	−0.452	.001	6	view →
CHOL	Male	All	+1.533	<.001	5	view →
LUSC	Male	All	+1.270	<.001	5	view →
BLCA	All	All	+0.783	.005	5	view →
PRAD	All	All	+0.447	.002	2	view →
ESCA	All	All	+0.961	.037	1	view →
KICH	All	All	−0.704	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HLTF–HNSC

Open the HNSC breakdown →