HLTF

Across TCGA pan-cancer cohorts, HLTF RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HLTF data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher HLTF RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HLTF expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KICH, KIRC, and LIHC are the cancer types where HLTF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	II,III,IV	0.568	0.954	.001	63	view →
KIRC	DFS	Median	All	0.732	0.521	<.001	51	view →
LIHC	DFS	Median	All	0.299	0.539	<.001	49	view →
LUSC	OS	Median	III,IV	0.570	0.766	<.001	35	view →
COAD	DFS	Quartile	IV	0.275	0.674	.002	34	view →
SARC	OS	Median	All	0.370	0.645	<.001	32	view →
ACC	DFS	Tertile	All	0.228	0.776	<.001	30	view →
UCEC	DFS	Quartile	All	0.795	0.916	<.001	30	view →
SKCM	DFS	Quartile	II,III,IV	0.299	0.122	.002	25	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
LGG	OS	Tertile	All	0.739	0.925	<.001	19	view →
THCA	DFS	Median	All	0.933	0.858	.002	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HLTF–KICH (DFS)

Open the KICH breakdown →