Across TCGA patient cohorts, HLA-Z RNA expression is significantly associated with the go_rna of many other GO terms, with 6,883 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible HLA-Z-associated GO terms across cancer lineages are Obsolete histone modification, Vesicle tethering, and Positive regulation of chromosome organization. Each is linked with HLA-Z in more than 27 cancer types. Because this analysis shows association rather than direction, both HLA-Z-to-partner and partner-to-HLA-Z results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-Z→partner) and Y-score (partner→HLA-Z) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Obsolete histone modification →	+0.064	+0.813	<.001	<.001	3	28
DLBC	Vesicle tethering →	+0.068	+1.060	<.001	<.001	3	27
DLBC	Positive regulation of chromosome organization →	+0.062	+1.107	<.001	<.001	3	27
DLBC	Nuclear-transcribed mRNA catabolic process →	+0.062	+0.892	<.001	<.001	3	27
ESCA	Autophagosome organization →	+0.054	+0.591	.004	<.001	3	27
DLBC	Post-Golgi vesicle-mediated transport →	+0.069	+0.884	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,883 associations by consensus.

Exploration

HLA-Z survival (RNA) · tumor vs normal (RNA) · all HLA-Z data types