HLA-Z

Across TCGA pan-cancer cohorts, HLA-Z RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated HLA-Z data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher HLA-Z RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HLA-Z expression acts as an unfavorable survival marker, although some lineages such as LUAD and LIHC show a favorable association.

CESC, UVM, and BLCA are the cancer types where HLA-Z RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.639	0.805	<.001	62	view →
UVM	DFS	Tertile	All	0.247	0.803	<.001	45	view →
BLCA	DFS	Tertile	All	0.434	0.625	.020	45	view →
COAD	DFS	Quartile	III,IV	0.502	0.751	.005	35	view →
THCA	DFS	Quartile	II,III,IV	0.858	0.916	.014	35	view →
OV	OS	Tertile	III,IV	0.603	0.700	.034	24	view →
ACC	DFS	Quartile	All	0.376	0.612	.012	21	view →
KICH	DFS	Quartile	II,III,IV	0.248	0.851	.005	12	view →
LUAD	DFS	Median	All	0.421	0.299	.021	12	view →
SKCM	DFS	Quartile	IV	0.152	0.557	.009	9	view →
THYM	OS	Tertile	III,IV	0.615	1.000	.019	9	view →
READ	DFS	Tertile	III,IV	0.327	0.799	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

HLA-Z–CESC (DFS)

Open the CESC breakdown →