HLA-V

Across TCGA patient cohorts, HLA-V mutation is significantly associated with the RNA expression of many other genes, with 1,234 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-V-associated genes across cancer lineages are RNU1-49P, NUDT3, and INO80B-WBP1. Each is linked with HLA-V in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-V-to-partner and partner-to-HLA-V results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-49P grouped by HLA-V-low versus HLA-V-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-V→partner) and Y-score (partner→HLA-V) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU1-49P →	+0.271	+6.993	<.001	<.001	3	2
UCEC	NUDT3 →	+0.412	+3.807	.001	<.001	3	1
UCEC	INO80B-WBP1 →	+0.103	+2.818	.001	.002	3	1
UCEC	RN7SL248P →	+0.086	+3.722	<.001	.001	3	1
UCEC	ZNF280B →	+0.627	+3.467	<.001	.002	3	1
SKCM	RNU6-1256P →	+0.351	+5.292	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,234 associations by consensus.

RNU1-49P by HLA-V expression — SKCM

Explore this box plot interactively →