HLA-V

Across TCGA pan-cancer cohorts, HLA-V RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated HLA-V data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HLA-V RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HLA-V expression acts as an unfavorable survival marker, although some lineages such as BLCA and ESCA show a favorable association.

HNSC, LUAD, and PAAD are the cancer types where HLA-V RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.701	0.797	<.001	69	view →
LUAD	DFS	Tertile	All	0.719	0.844	.002	41	view →
PAAD	OS	Quartile	All	0.324	0.608	<.001	36	view →
BLCA	OS	Median	II,III,IV	0.756	0.659	.005	32	view →
THCA	DFS	Quartile	II,III,IV	0.530	0.880	.009	26	view →
ESCA	DFS	Quartile	All	0.674	0.467	.020	24	view →
OV	OS	Tertile	All	0.272	0.384	.010	22	view →
UCS	DFS	Quartile	II,III,IV	0.611	0.125	.016	20	view →
LGG	DFS	Quartile	All	0.646	0.803	.002	16	view →
GBM	OS	Tertile	All	0.208	0.325	.011	15	view →
LUSC	DFS	Quartile	III,IV	0.247	0.563	.006	15	view →
LIHC	OS	Quartile	III,IV	0.396	0.804	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

HLA-V–HNSC (OS)

Open the HNSC breakdown →