HLA-V

Across TCGA pan-cancer cohorts, HLA-V RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HLA-V’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-V RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-V is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where HLA-V tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-V RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+1.158	<.001	12	view →
HNSC	All	All	+0.705	<.001	12	view →
KICH	Male	All	−0.901	<.001	10	view →
LUAD	Female	III,IV	−1.578	<.001	9	view →
LUSC	Female	II,III,IV	−2.197	<.001	8	view →
PAAD	Female	All	+1.350	.005	4	view →
KIRP	All	All	+0.576	.001	4	view →
UCEC	All	All	−0.336	<.001	4	view →
LIHC	Female	II,III,IV	+0.191	.045	2	view →
PRAD	All	All	−0.160	.039	2	view →
CHOL	All	All	+0.616	.011	1	view →
BLCA	Male	III,IV	+0.468	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HLA-V–KIRC

Open the KIRC breakdown →