HLA-DQB2

Across TCGA patient cohorts, HLA-DQB2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,274 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DQB2-associated genes across cancer lineages are HLA-DQA2, HLA-DRB6, and CD2. Each is linked with HLA-DQB2 in more than 7 cancer types. Because this analysis shows association rather than direction, both HLA-DQB2-to-partner and partner-to-HLA-DQB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DQB2 versus HLA-DQA2 in CCRCC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQB2→partner) and Y-score (partner→HLA-DQB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HLA-DQA2 →	+4.150	+1.366	<.001	<.001	3	8
BRCA	HLA-DRB6 →	+2.252	+1.220	<.001	<.001	3	7
GBM	CD2 →	+1.872	+1.562	<.001	<.001	3	6
HNSC	HLA-DPB1 →	+1.175	+0.710	.002	.002	3	6
GBM	HLA-DMB →	+1.943	+1.505	<.001	<.001	3	6
CCRCC	TRAC →	+1.340	+0.922	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,274 associations by consensus.

HLA-DQB2 vs HLA-DQA2 — CCRCC

Explore this scatter interactively →